Min Chen

Summary

My primary research focuses on developing novel biosynthetic methods for oligosaccharide and polysaccharide protein vaccines and investigating the immunological mechanisms underlying these vaccines.

I have led and participated in several projects funded by the National Natural Science Foundation, major new drug initiatives, the 973 Program, the 863 Program, and significant Ministry of Education projects. Over the past five years, I have published over 40 peer-reviewed papers as first or corresponding author in international journals. I hold five granted invention patents. Additionally, I serve as a reviewer for various governmental and regional funding proposals and have been invited to chair international conferences and specialized meetings and to deliver keynote presentations on multiple occasions.

Microbiology

Past or current institution affiliations

Publications

1. Qingyun Meng, Kun Li, Yongheng Rong, Qizheng Wu, Xunlian Zhang, Yun Kong∗, Min Chen∗∗, Probing peptide substrate specificities of N-glycosyltranferase isoforms from different bacterial species, Carbohydrate Research 473 (2019) 82–87
2. Xinyuan Hu, Xin Pang, Peng George Wang, Min Chen,Isolation and Characterization of an Antioxidant Exopolysaccharide Produced by Bacillus sp. S-1 from Sichuan Pickles Carbohydrate Polymers，Volume 204, 15 January 2019, Pages 9-16
3. L. L. Chen, D. L. Han, Y. F. Zhai, J. H. Wang, Y. F. Wang, and M. Chen* Characterization and Mutational Analysis of Two UDPGalactose 4 Epimerases in Streptococcus pneumoniae TIGR4，Biochemistry (Moscow), 2018, Vol. 83, No. 1, pp. 3744
4. Wu Qizheng, Zhong Hui, Zhai Yafei, Jia Yanjiong, Yin Zhinan, Chen Min*, Yang Hengwen and Wang Peng George, Gut microbiota have blood types as human；Science Bulletin 63, 1311
5. Kong, Yun; Li, Jiang; Hu, Xinyuan; Wang, Yaoguang; Meng, Qingyun; Gu, Guofeng; Wang, Peng George; Chen, Min*; N-Glycosyltransferase from Aggregatibacter aphrophilus synthesizes glycopeptides with relaxed nucleotide-activated sugar donor selectivity，Carbohydrate Research462, pp 7-12, 2018-6-15
6. Chen, Min; Li, Yuanyuan; Liu, Zhu; Qu, Yajun; Zhang, Huajie; Li, Dengwen; Zhou, Jun; Xie, Songbo; Liu, Min, Exopolysaccharides from a Codonopsis pilosula endophyte activate macrophages and inhibit cancer cell proliferation and migration, Thoracic Cancer, 9(5), pp 630-639, 2018-5
7 Kong, Yun; Qu, Yajun; Wang, Shengjun; Wang, Peng George; Chen, Min; * Heterologous expression of Shigella dysenteriae serotype 1 O-antigen analog in Escherichia coli K-12 W3110 by transferring a minimum number of genes involved in O-polysaccharide biosynthesis。Biotechnology Letters.40(8), pp 1219-1226, 2018-8
8 Zhongrui Ma, Huajie Zhang, Peng George Wang, Xian-Wei Liu and Min Chen* ，Peptide adjacent to glycosylation sites impacts immunogenicity of glycoconjugate vaccine，Oncotarget, 2018, Vol. 9, (No. 1), pp: 75-82
9. Wu, Qizheng ，Zhang, Houcheng，Wang, Peng Gorge，Chen, Min*，Evaluation of the efficacy and safety of Ganoderma lucidum mycelium-fermented liquid on gut microbiota and its impact on cardiovascular risk factors in human，RSC Adv., 2017,7, 45093 –45100
10. Inka Brockhausen, Dileep G. Nair, Min Chen, Xiaojing Yang, John S. Allingham, Walter A. Szarek,and Tassos Anastassiades, Human acetyl-CoA:glucosamine-6-phosphate N-acetyltransferase 1 has a relaxed donor specificity and transfers acyl groups up to four carbons in length, Biochem. Cell Biol. 94: 197–204 (2016)
11. Wenjing Shang, YafeiZhai, Zhongrui Ma, Gongjin Yang, Yan Ding, Donglei Han, Jiang Li,
Houcheng Zhang, Jun Liu，Peng George Wang, Xian-wei Liu,*，Min Chen*，Production of human blood group B antigen epitopeconjugated protein in Escherichia coli and utilization of the adsorptionblood group B antibody，Microbial Cell Factories (2016) 5:138
12. Zhang H, Wang B, Ma Z, Wei M, Liu J, Li D, Zhang H, Wang PG, Chen M*，l-Rhamnose Enhances the Immunogenicity of Melanoma-Associated Antigen A3 for Stimulating Antitumor Immune Responses, Bioconjug Chem. 2016 Apr 20;27(4):1112-8.